Ultrasound erosions in the feet best predict progression to inflammatory arthritis in anti-CCP positive at-risk individuals without clinical synovitis

• Published in: Annals of the rheumatic diseases Vol. 79; no. 7; pp. 901 - 907
• Main Authors: Di Matteo, Andrea, Mankia, Kulveer, Duquenne, Laurence, Cipolletta, Edoardo, Wakefield, Richard J, Garcia-Montoya, Leticia, Nam, Jacqueline Leong, Emery, Paul
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.07.2020
• Subjects: Biomarkers; Citrulline; Clinical medicine; Feet; Hypertrophy; Inflammation; Joint diseases; Normal distribution; Peptides; Rheumatoid arthritis; Rheumatoid factor; Rheumatology; Studies; Synovitis; Ultrasonic imaging; Ultrasound; X-rays; United Kingdom > UK; ant-CCP; early rheumatoid arthritis; ultrasonography; rheumatoid arthritis
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2020-217215

ObjectivesTo investigate, in anti-cyclic citrullinated peptide antibody positive (CCP+) at-risk individuals without clinical synovitis, the prevalence and distribution of ultrasound (US) bone erosions (BE), their correlation with subclinical synovitis and their association with the development of inflammatory arthritis (IA).MethodsBaseline US scans of 419 CCP+ at-risk individuals were analysed. BE were evaluated in the classical sites for rheumatoid arthritis damage: the second and fifth metacarpophalangeal (MCP2 and MCP5) joints, and the fifth metatarsophalangeal (MTP5) joints. US synovitis was defined as synovial hypertrophy (SH) ≥2 or SH ≥1+power Doppler signal ≥1. Subjects with ≥1 follow-up visit were included in the progression analysis (n=400).ResultsBE were found in ≥1 joint in 41/419 subjects (9.8%), and in 55/2514 joints (2.2%). The prevalence of BE was significantly higher in the MTP5 joints than in the MCP joints (p<0.01). A significant correlation between BE and US synovitis in the MTP5 joints was detected (Cramer’s V=0.37, p<0.01). The OR for the development of IA (ever) was highest for the following: BE in >1 joint 10.6 (95% CI 1.9 to 60.4, p<0.01) and BE and synovitis in ≥1 MTP5 joint 5.1 (95% CI 1.4 to 18.9, p=0.02). In high titre CCP+ at-risk individuals, with positive rheumatoid factor and BE in ≥1 joint, the OR increased to 16.9 (95% CI 2.1–132.8, p<0.01).ConclusionsIn CCP+ at-risk individuals, BE in the feet appear to precede the onset of clinical synovitis. BE in >1 joint, and BE in combination with US synovitis in the MTP5 joints, are the most predictive for the development of clinical arthritis.