Insight into the medicinal chemistry of the endocannabinoid hydrolase inhibitors

Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particu...

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Bibliographic Details
Published inCurrent medicinal chemistry Vol. 20; no. 14; p. 1824
Main Authors Kapanda, C N, Poupaert, J H, Lambert, D M
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.05.2013
Subjects
Amidohydrolases - antagonists & inhibitors
Amidohydrolases - chemistry
Amidohydrolases - metabolism
Animals
Chemistry, Pharmaceutical - methods
Endocannabinoids - chemistry
Endocannabinoids - metabolism
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Humans
Structure-Activity Relationship
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Summary:Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.
ISSN:1875-533X
DOI:10.2174/09298673113209990108