Serial Monoxenous Transmission of Toxoplasma gondii in Cats

Oral administration of Toxoplasma gondii oocysts to cats (i.e., monoxenous transmission) typically induces patent infections in fewer than half of test subjects. In the present study, oral administration of T. gondii oocysts to 5 kittens induced a patent infection in 2 of them, but only 1 kitten she...

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Published inThe Journal of parasitology Vol. 99; no. 6; pp. 1122 - 1124
Main Authors Awobode, H. O, Paul, A. J, Sengoku-Graham, H, Clem, R. W, Mateus-Pinilla, N. E, McAllister, M. M
Format Journal Article
LanguageEnglish
Published United States American Society of Parasitologists 01.12.2013
Allen Press Inc
Subjects
Animal euthanasia
Animals
Cat Diseases - parasitology
Cat Diseases - transmission
Cats
Foodborne illnesses
Infections
Kittens
Laboratories
Male
Mice
Mice, Inbred ICR
Oocysts
Oocysts - physiology
Oral administration
Parasitology
Protozoa
RESEARCH NOTES
Serial Passage - methods
Serial Passage - veterinary
Swine
Tachyzoites
Toxoplasma - physiology
Toxoplasma gondii
Toxoplasmosis, Animal - parasitology
Toxoplasmosis, Animal - transmission
Transmission efficiency
United States > US
Illinois
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Summary:Oral administration of Toxoplasma gondii oocysts to cats (i.e., monoxenous transmission) typically induces patent infections in fewer than half of test subjects. In the present study, oral administration of T. gondii oocysts to 5 kittens induced a patent infection in 2 of them, but only 1 kitten shed enough oocysts to enable further study. Those monoxenously-produced oocysts were administered to another kitten, which produced a second generation of monoxenous oocysts, and then those were used to induce a third generation of monoxenous oocysts. These results provide a rationale to develop a strain of T. gondii that has efficient direct transmission. The isolate of T. gondii that was able to be passaged in this manner has been designated the Dubey strain and cultured tachyzoites have been donated to a repository.
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ISSN:0022-3395
1937-2345
1937-2345
DOI:10.1645/13-280.1