Even ‘safe’ medications need to be administered with care

• Published in: BMJ case reports Vol. 2013; p. bcr2012006204
• Main Authors: Lutwak, Nancy, Howland, Mary Ann, Gambetta, Rosemarie, Dill, Curt
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 02.01.2013; BMJ Publishing Group
• Series: Reminder of important clinical lesson
• Subjects: Anesthesia; Anesthetics, Local - adverse effects; Anesthetics, Local - metabolism; Ataxia; Ataxia - chemically induced; Bronchoscopy; Cardiac arrhythmia; Case reports; Diplopia; Diplopia - chemically induced; Drug dosages; Humans; Lidocaine - adverse effects; Lidocaine - metabolism; Liver cirrhosis; Liver Cirrhosis - metabolism; Liver diseases; Male; Medical practices; Metabolism; Metabolites; Middle Aged; Oral administration; Patients; Reminder of Important Clinical Lesson; Toxicity; USA/Canada; White
• ISSN: 1757-790X; 1757-790X
• DOI: 10.1136/bcr-2012-006204

A 60-year-old man with a history of hepatic cirrhosis and cardiomyopathy underwent transoesophageal echocardiogram. He received mild sedation and topical lidocaine. During the recovery period the patient developed ataxia and diplopia for about 30 mins, a result of lidocaine toxicity. The patient was administered a commonly used local anaesthetic, a combination of 2% viscous lidocaine, 4% lidocaine gargle and 5% lidocaine ointment topically to the oropharnyx. The total dose was at least 280 mg. Oral lidocaine undergoes extensive first pass metabolism and its clearance is quite dependent on rates of liver blood flow as well as other factors. The patient's central nervous system symptoms were mild and transient but remind us that to avoid adverse side effects, orally administered drugs with fairly high hepatic extraction ratio given to patients with chronic liver disease need to be given in reduced dosages. Even ‘Safe’ medications need to be carefully administered.