Evolving therapeutic targets in ischemic stroke: a concise review

Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targ...

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Bibliographic Details
Published inCurrent drug targets Vol. 14; no. 4; p. 497
Main Authors Sugunan, Sinoy, Joseph, Diya Binoy, Rajanikant, G K
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.04.2013
Subjects
Animals
Brain Ischemia - drug therapy
Brain Ischemia - metabolism
Humans
Molecular Targeted Therapy
Proteins - metabolism
Stroke - drug therapy
Stroke - metabolism
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Summary:Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.
ISSN:1873-5592
DOI:10.2174/1389450111314040011