Delayed interval of involvement of the second eye in a male patient with bilateral Chandler's syndrome

• Published in: British journal of ophthalmology Vol. 96; no. 1; pp. 134 - 135
• Main Authors: Lobo, A-M, Rhee, D J
• Format: Journal Article
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.01.2012; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Adult; bilateral involvement; Biological and medical sciences; Cataracts; Chandler's syndrome; chronic angle-closure glaucoma; cornea; Corneal Endothelial Cell Loss - pathology; Corneal Endothelial Cell Loss - physiopathology; diagnostic tests/investigation; Disease Progression; Endothelium; Eye; Family medical history; Glaucoma; Glaucoma, Angle-Closure - pathology; Glaucoma, Angle-Closure - physiopathology; Glaucoma, Angle-Closure - surgery; Humans; intraocular pressure; Iridocorneal Endothelial Syndrome - pathology; Iridocorneal Endothelial Syndrome - physiopathology; Iridocorneal Endothelial Syndrome - surgery; Lasers; Male; Malformations of the eye; Medical sciences; Microscopy; Miscellaneous; Ophthalmology; Pathology; Patients; specular microscopy; Trabeculectomy; Human; Eye; Eye disease; Chandler syndrome; Malformation; Bilateral; Male; Ophthalmology; Congenital disease; Delay
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.2009.177931

Another study reported 28 patients with subclinical endothelial abnormalities, including increased variation of cell area and decreased percentage of hexagonal cells compared with normal controls. 10 The presence of endothelial abnormalities in the asymptomatic eyes of patient's with ICE raises the question as to whether this can truly be called a unilateral disease process. Chandler originally described a syndrome where abnormalities of the posterior aspect of the cornea were present with minimal iris atrophy and no hole formation. 1 13 The pathogenesis of ICE syndrome is related to abnormal endothelial cells which create a membrane that grows over the angle structures and causes atrophy of the iris. 1 With regard to the histopathologic findings from the enucleated eye, the endothelial cell count and corneal stromal oedema could have been further compromised from the multiple prior glaucoma surgeries including two trabeculectomies and glaucoma drainage device as this consequence has been documented by other investigators. 14 If there are endothelial abnormalities in both eyes, it is unknown why the endothelial changes in one eye are confined to the subclinical level.