DNA repair mechanisms in colorectal carcinogenesis
Colon cancer is among the most common cancers and the third cause of cancer deaths worldwide. If detected at an early stage, treatment might often lead to cure. The present review adduces the so far studied alterations in the expression of genes, as well as polymorphisms of genes engaged in DNA repa...
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Published in | Current molecular medicine Vol. 12; no. 3; p. 237 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
01.03.2012
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Subjects | |
Online Access | Get more information |
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Summary: | Colon cancer is among the most common cancers and the third cause of cancer deaths worldwide. If detected at an early stage, treatment might often lead to cure. The present review adduces the so far studied alterations in the expression of genes, as well as polymorphisms of genes engaged in DNA repair systems, with particular emphasis on indirect ones that are correlated with colorectal cancer. Such aberrations could be linked to an increased risk for the development of colorectal cancer and might serve as potential targets in the areas of prevention and therapy. |
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ISSN: | 1875-5666 |
DOI: | 10.2174/156652412799218859 |