DNA repair mechanisms in colorectal carcinogenesis

Colon cancer is among the most common cancers and the third cause of cancer deaths worldwide. If detected at an early stage, treatment might often lead to cure. The present review adduces the so far studied alterations in the expression of genes, as well as polymorphisms of genes engaged in DNA repa...

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Bibliographic Details
Published inCurrent molecular medicine Vol. 12; no. 3; p. 237
Main Authors Michailidi, C, Papavassiliou, A G, Troungos, C
Format Journal Article
LanguageEnglish
Published Netherlands 01.03.2012
Subjects
Animals
Biomarkers, Tumor - genetics
Colorectal Neoplasms - genetics
DNA Repair - genetics
Genetic Predisposition to Disease
Humans
Polymorphism, Genetic - genetics
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Summary:Colon cancer is among the most common cancers and the third cause of cancer deaths worldwide. If detected at an early stage, treatment might often lead to cure. The present review adduces the so far studied alterations in the expression of genes, as well as polymorphisms of genes engaged in DNA repair systems, with particular emphasis on indirect ones that are correlated with colorectal cancer. Such aberrations could be linked to an increased risk for the development of colorectal cancer and might serve as potential targets in the areas of prevention and therapy.
ISSN:1875-5666
DOI:10.2174/156652412799218859