Correlation of autoantibodies and CD5+ B cells in ocular adnexal marginal zone B cell lymphomas

• Published in: Journal of clinical pathology Vol. 63; no. 1; pp. 79 - 82
• Main Authors: Kubota, T, Moritani, S, Yoshino, T, Nagai, H, Terasaki, H
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.01.2010; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Aged; Aged, 80 and over; Antibodies, Antinuclear - blood; Autoantibodies - blood; Autoimmunity; B-Lymphocyte Subsets - immunology; Biological and medical sciences; Case-Control Studies; CD5 Antigens - blood; Cell Proliferation; DNA, Single-Stranded - immunology; Female; Genes; Hematologic and hematopoietic diseases; Humans; Immunoglobulins; Investigative techniques, diagnostic techniques (general aspects); Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphocyte receptors; Lymphoma; Lymphoma, B-Cell, Marginal Zone - immunology; Lymphoma, B-Cell, Marginal Zone - pathology; Medical sciences; Middle Aged; Orbital Neoplasms - immunology; Orbital Neoplasms - pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Autoimmunity; Human; Antibody; Marginal zone lymphoma; Autoantibody; Malignant hemopathy; B-Lymphocyte; Visual system; Eye disease; Anatomic pathology; Chronic; Lymphoproliferative syndrome; Cancer
• ISSN: 0021-9746; 1472-4146
• DOI: 10.1136/jcp.2009.067603

Aim:To determine the clinicopathological properties of ocular adnexal marginal zone B cell lymphomas (MZBLs) with CD5+ B cells.Methods:This study determined the clinicopathological properties of MZBL samples from 97 patients with ocular adnexal MZBLs and searched for hallmarks of systemic autoimmunity in these patients.Results:Two elderly female patients were found to have ocular adnexal MZBLs with CD5+ B cells; flow cytometry analysis suggested that one of these MZBLs had CD5+ B cell clonal proliferation. The levels of anti-single stranded (SS)-DNA and anti-SS-A/Ro antibodies in these two patients were significantly higher than those in controls that were matched for age, gender and disease (2/2 versus 0/14; p = 0.008) and controls without MZBL (2/2 versus 0/30; p = 0.002). The genes from the immunoglobulin heavy-chain variable region for one of the patients showed a V3-21 segment. In addition, another patient with ocular adnexal reactive lymphoid hyperplasia with CD5+ B cells also had anti-SS-DNA antibodies.Conclusion:Patients with ocular adnexal MZBLs with CD5+ B cells may have a background of systemic conditions with CD5+ B-cell-related autoantibodies.