Novel Medical Therapies in Meningiomas

Meningiomas are the most common primary brain tumor in adults and have been historically managed with surgery and radiation therapy. However, in patients with inoperable, recurrent or high-grade tumors, medical therapy is often needed. Traditional chemotherapy and hormone therapy have been largely i...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 1416; p. 213
Main Authors Danish, Husain, Brastianos, Priscilla
Format Journal Article
LanguageEnglish
Published United States 01.01.2023
Subjects
Molecular targets
Systemic therapy
Chemotherapy
Immunotherapy
Clinical trials
Hormonal
Immunobiology
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Summary:Meningiomas are the most common primary brain tumor in adults and have been historically managed with surgery and radiation therapy. However, in patients with inoperable, recurrent or high-grade tumors, medical therapy is often needed. Traditional chemotherapy and hormone therapy have been largely ineffective. However, with improved understanding of the molecular drivers in meningioma, there has been increasing interest in targeted molecular and immune therapies. In this chapter, we will discuss recent advances in meningioma genetics and biology and review current clinical trials with targeted molecular treatment and other novel therapies.
ISSN:0065-2598
DOI:10.1007/978-3-031-29750-2_16