On chemical structures with potent antiepileptic/anticonvulsant profile

Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. There has been a considerable interest in the development of many antiepileptic and anticonvulsant agents for controlling epilepsy with fewer side effects and improvement of quality of life. Since the...

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Published inMini reviews in medicinal chemistry Vol. 12; no. 7; p. 671
Main Authors Aboul-Enein, M N, El-Azzouny, A A, Saleh, O A, Maklad, Y A
Format Journal Article
LanguageEnglish
Published Netherlands 01.06.2012
Subjects
Animals
Anticonvulsants - chemistry
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Humans
Seizures - drug therapy
Seizures - metabolism
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Summary:Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. There has been a considerable interest in the development of many antiepileptic and anticonvulsant agents for controlling epilepsy with fewer side effects and improvement of quality of life. Since the terms antiepileptics /anticonvulsants are used interchangeably, this article reviews their classification according to the chemical structure into: hydantoins, oxazolidinediones, succinimides, barbiturates, amides, benzodiazepines, valproic acid and its derivatives, GABA-analogues, cycloalkanes, semicarbazones, γ butyrolactones (GBLs), imidaquinazolines and pyrrolidine derivatives as well as miscellaneous compounds. In addition, the review discusses the different mechanisms of action of antiepileptic and anticonvulsant agents.
ISSN:1875-5607
DOI:10.2174/138955712800626665