Non-invasive approaches to visualize the endothelin axis in vivo using state-of-the-art molecular imaging modalities

The endothelin axis plays a major role in cardiovascular diseases and a number of human cancers. This review summarizes the work that has been published in the past ten years using labeled endothelin receptor ligands for the visualization of endothelin receptor expression in vivo.

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Bibliographic Details
Published inMini reviews in medicinal chemistry Vol. 9; no. 14; p. 1580
Main Authors Höltke, C, Faust, A, Breyholz, H-J, Kopka, K, Schober, O, Riemann, B, Bremer, C, Schäfers, M, Wagner, S
Format Journal Article
LanguageEnglish
Published Netherlands 01.12.2009
Subjects
Amino Acid Sequence
Animals
Endothelins - biosynthesis
Endothelins - metabolism
Ligands
Molecular Imaging
Molecular Sequence Data
Rats
Receptors, Endothelin - chemistry
Receptors, Endothelin - metabolism
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Summary:The endothelin axis plays a major role in cardiovascular diseases and a number of human cancers. This review summarizes the work that has been published in the past ten years using labeled endothelin receptor ligands for the visualization of endothelin receptor expression in vivo.
ISSN:1875-5607
DOI:10.2174/138955709791012210