Emergence of the concept of platelet reactivity monitoring of response to thienopyridines
Clinical trials have demonstrated the beneficial impact of clopidogrel in preventing major adverse cardiovascular events (MACE), particularly in patients undergoing percutaneous coronary intervention (PCI). The concept of biological clopidogrel resistance emerged with the finding of persistent plate...
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Published in | Heart Vol. 95; no. 15; pp. 1214 - 1219 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article Book Review |
Language | English |
Published |
London
BMJ Publishing Group Ltd and British Cardiovascular Society
01.08.2009
BMJ Publishing Group BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | Clinical trials have demonstrated the beneficial impact of clopidogrel in preventing major adverse cardiovascular events (MACE), particularly in patients undergoing percutaneous coronary intervention (PCI). The concept of biological clopidogrel resistance emerged with the finding of persistent platelet activation despite clopidogrel therapy in some patients. Further, a link between biological clopidogrel resistance and thrombotic recurrence after PCI was observed and a threshold of platelet reactivity (PR) for thrombotic events was suggested. Consistently, in recent trials, enhanced PR inhibition translated into a reduction in the rate of MACE after PCI. This review aims to present the emergence of the concept of PR monitoring in patients undergoing PCI following recent advances in this field. |
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Bibliography: | istex:49782215F238655E6E0F188E0CA3AA4EA3D57999 ArticleID:ht152660 href:heartjnl-95-1214.pdf PMID:19196732 local:heartjnl;95/15/1214 ark:/67375/NVC-0M1FVFN6-5 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1355-6037 1468-201X |
DOI: | 10.1136/hrt.2008.152660 |