Saponins in tumor therapy

Saponins are plant glycosides with favorable anti-tumorigenic properties. Several saponins inhibit tumor cell growth by cell cycle arrest and apoptosis with IC50 values of up to 0.2 microM. We discuss diverse groups of saponins (dioscins, saikosaponins, julibrosides, soy saponins, ginseng saponins a...

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Published inMini reviews in medicinal chemistry Vol. 8; no. 6; p. 575
Main Authors Bachran, Christopher, Bachran, Silke, Sutherland, Mark, Bachran, Diana, Fuchs, Hendrik
Format Journal Article
LanguageEnglish
Published Netherlands 01.06.2008
Subjects
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Cell Line, Tumor
Humans
Neoplasms - drug therapy
Saponins - chemistry
Saponins - classification
Saponins - therapeutic use
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Summary:Saponins are plant glycosides with favorable anti-tumorigenic properties. Several saponins inhibit tumor cell growth by cell cycle arrest and apoptosis with IC50 values of up to 0.2 microM. We discuss diverse groups of saponins (dioscins, saikosaponins, julibrosides, soy saponins, ginseng saponins and avicins) investigated in relation to tumor therapy and focus on cellular and systemic mechanisms of tumor cell growth inhibition both in vitro and in vivo. The review also describes saponins in combination with conventional tumor treatment strategies, which result in improved therapeutic success. Some combinations of saponins and anti-tumorigenic drugs induce synergistic effects with potentiated growth inhibition.
ISSN:1389-5575
DOI:10.2174/138955708784534445