NMR structure/function relationships of peptides corresponding to the C1B1 Region of PKC gamma

The region (101-112) of C1B domain in PKC gamma plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for t...

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Bibliographic Details
Published inProtein and peptide letters Vol. 17; no. 1; p. 1
Main Authors Lauer, Jason, Banerjee, Debarshi, Shanks, Denton, Dai, Huaien, Gong, Yu-Xi, Prakash, Om, Takemoto, Dolores
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2010
Subjects
14-3-3 Proteins - metabolism
Amino Acid Sequence
Animals
Binding, Competitive
Cell Survival
Cells, Cultured
Gap Junctions
Models, Biological
Molecular Sequence Data
Mutation
Nuclear Magnetic Resonance, Biomolecular - methods
Peptides - chemistry
Peptides - genetics
Peptides - metabolism
Protein Kinase C - chemistry
Protein Kinase C - genetics
Protein Kinase C - metabolism
Protein Structure, Tertiary - genetics
Rabbits
Structure-Activity Relationship
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Summary:The region (101-112) of C1B domain in PKC gamma plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.
ISSN:1875-5305
DOI:10.2174/092986610789909485