Postnatal development of brain TRH, serum TSH and thyroid hormones in the male and female rat

The postnatal development of immunoreactive TRH in the central nervous system (CNS), serum TSH and thyroid hormones was studied in both male and female normal rats. While in most structures of the CNS, TRH increased until day 20–30, serum TSH values peaked at day 15 as did T4. Significant difference...

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Published inActa endocrinologica (Copenhagen) Vol. 112; no. 1; pp. 7 - 11
Main Authors Gayo, L, Bonet, B, Herranz, A S, Iglesias, R, Toro, M J, Montoya, E
Format Journal Article
LanguageEnglish
Published Denmark 01.05.1986
Subjects
Age Factors
Animals
Brain - metabolism
Female
Hypothalamus
Pituitary Gland - growth & development
Rats
Rats, Inbred Strains
Sex Factors
Thyroid Gland - growth & development
Thyrotropin - blood
Thyrotropin-Releasing Hormone - metabolism
Thyroxine - blood
Triiodothyronine - blood
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Summary:The postnatal development of immunoreactive TRH in the central nervous system (CNS), serum TSH and thyroid hormones was studied in both male and female normal rats. While in most structures of the CNS, TRH increased until day 20–30, serum TSH values peaked at day 15 as did T4. Significant differences were also obtained between both sexes in these parameters. These data further support the fact that pituitary-thyroid axis maturation is independent of brain TRH.
ISSN:0804-4643
0001-5598
1479-683X
DOI:10.1530/acta.0.1120007