Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension

• Published in: Indian journal of medical sciences Vol. 61; no. 6; pp. 326 - 331
• Main Authors: Nandeesha, H, Sathiyapriya, V, Zachariah, Bobby, Pavithran, P, Agrawal, Aparna, Selvaraj, N
• Format: Journal Article
• Language: English
• Published: India Medknow Publications on behalf of Indian Journal of Medical Sciences Trust 01.06.2007; Medknow Publications and Media Pvt. Ltd; Medip Academy
• Subjects: Adult; Antioxidants; Antioxidants - metabolism; Blood Glucose - metabolism; Catalase - blood; Development and progression; Diagnosis; essential hypertension; Glutathione - blood; Glutathione Peroxidase - blood; Health aspects; Humans; Hypertension; Hypertension - blood; Hypertension - metabolism; Linear Models; Male; Obesity; Oxidative Stress; Protein Carbonylation; Severity of Illness Index; India
• ISSN: 0019-5359; 1998-3654
• DOI: 10.4103/0019-5359.32679

Background : Although a wide number of experimental evidences are available regarding oxidant-antioxidant disturbance in hypertension, clinical data supporting it is lacking in men in early stages of hypertension. Aims: The objective of the study was to evaluate oxidative status and antioxidant activities in males with stage I essential hypertension. Materials and Methods : Thirty hypertensives and 21 normotensives were included in the study. Protein carbonyl, reduced glutathione, glutathione peroxidase, catalase and fasting glucose were assessed in both the groups. Statistical Analysis : Results were analyzed by student′s ′t′ test and linear regression analysis test. Results : Plasma protein carbonyl and glutathione peroxidase were significantly increased, and catalase and GSH were significantly reduced in the hypertensive group compared to normotensive subjects. There was a significant negative correlation between glutathione peroxidase and catalase in the test group. Conclusions : The data from the present study indicates an alteration in oxidant-antioxidant status in non-obese men in early stages of essential hypertension.