Essential Thrombocythaemia and Peripheral Gangrene
Six patients are described in whom gangrene of one or more toes occurred as the presenting feature of essential thrombocythaemia. Spontaneous platelet aggregation was observed in platelet-rich plasma from four patients and platelet aggregation after the addition of adenosine diphosphate and collagen...
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Published in | British Medical Journal Vol. 3; no. 5930; pp. 548 - 552 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
British Medical Journal Publishing Group
31.08.1974
British Medical Association BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | Six patients are described in whom gangrene of one or more toes occurred as the presenting feature of essential thrombocythaemia. Spontaneous platelet aggregation was observed in platelet-rich plasma from four patients and platelet aggregation after the addition of adenosine diphosphate and collagen was highly abnormal in samples from all six. All of the patients described dramatic relief of pain within six hours of ingestion of aspirin and this coincided with disappearance of the spontaneous platelet aggregation and collagen-induced platelet aggregation. Treatment with phosphorus-32 corrected the platelet count and there were no further recurrences of peripheral vascular disease. Platelet function tests performed at the time all gave normal results. It is concluded that essential thrombocythaemia is an important and treatable cause of peripheral vascular disease. |
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Bibliography: | ark:/67375/NVC-8BRWWDZ8-R PMID:4472103 istex:8793D98D91C32DA90B638714B859F92F26FADF9B local:bmj;3/5930/548 href:bmj-3-548.pdf ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-1447 1468-5833 |
DOI: | 10.1136/bmj.3.5930.548 |