Human Mammary Tumor Virus (HMTV) in Endometrial Carcinoma

ObjectiveHuman mammary tumor virus (HMTV) is 90% to 98% homologous to mouse mammary tumor virus, the etiological agent of mammary tumors in mice. Human mammary tumor virus sequences were found in 40% of the breast cancers studied in both American and Australian women. In addition, 10% of endometrial...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of gynecological cancer Vol. 23; no. 8; pp. 1423 - 1428
Main Authors Deligdisch, Liane, Marin, Tania, Lee, Anna T., Etkind, Polly, Holland, James F., Melana, Stella, Pogo, Beatriz G.T.
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 01.10.2013
Subjects
Adult
Aged
Aged, 80 and over
Animals
Base Sequence
Breast cancer
Cancer
Carcinoma - virology
Case-Control Studies
Endometrial cancer
Endometrial Neoplasms - virology
Female
Genes, env
Humans
Mice
Middle Aged
Molecular Sequence Data
Retroviridae - genetics
Retroviridae - isolation & purification
Vitamin E
Online AccessGet full text

Cover

More Information
Summary:ObjectiveHuman mammary tumor virus (HMTV) is 90% to 98% homologous to mouse mammary tumor virus, the etiological agent of mammary tumors in mice. Human mammary tumor virus sequences were found in 40% of the breast cancers studied in both American and Australian women. In addition, 10% of endometrial carcinomas studied in Australian women also contained HMTV sequences. We have explored the possibility that endometrial cancer of American women may also contain HMTV.Methods/MaterialsNested polymerase chain reactions, radioactive internal probing, and sequencing were used to establish the presence of unique nucleotide sequences of HMTV in human genomic DNA. The genomic DNAs were tested to guarantee that they were free of murine DNA. Immunohistochemistry with a monoclonal antibody specific for HMTV envelope protein demonstrated that HMTV sequences were translated.ResultsThirteen (23.2%) of 56 of the endometrial cancers studied contained HMTV sequences and proteins. Human mammary tumor virus sequences and protein were not detected in the 33 normal endometria studied.ConclusionHuman mammary tumor virus, an agent with high homology to mouse mammary tumor virus, was found in 23.2% of the endometrial cancers studied, thus opening the possibility of a pathogenic role.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1048-891X
1525-1438
DOI:10.1097/IGC.0b013e3182980fc5