Efficacy and safety of acupuncture therapy for Parkinson’s disease with neuropsychiatric symptoms: protocol for a systematic review and meta-analysis

• Published in: BMJ open Vol. 14; no. 5; p. e081041
• Main Authors: Tan, Weiqiang, Liu, Qing, Cen, Mingjun, Leong, Ian I, Pan, Zhaoquan, Liao, Muxi, Zhuang, Lixing
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 28.05.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Protocol
• Subjects: Acupuncture; Acupuncture Therapy - methods; Adult psychiatry; Antipsychotics; Anxiety; Apathy; Bias; Chinese medicine; Citation indexes; Clinical trials; Cognitive ability; Disease; Drug dosages; Electroacupuncture; Humans; Medical research; Meta-analysis; Meta-Analysis as Topic; Movement disorders; Neurology; Parkinson Disease - complications; Parkinson Disease - therapy; Parkinson's disease; Psychotropic drugs; Quality of Life; Randomized Controlled Trials as Topic; Research Design; Software; Systematic review; Systematic Reviews as Topic; Treatment Outcome; China; Neurology; Adult psychiatry; Parkinson-s disease
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2023-081041

IntroductionNeuropsychiatric symptoms (NPS) are common non-motor symptoms among patients with Parkinson’s disease (PD) and significantly impact their overall quality of life detrimentally. Several studies have reported the clinical effect of acupuncture therapy in treating NPS in PD. Therefore, the objective of this systematic review is to evaluate the potential inclusion of acupuncture therapy as an integral component of complementary treatment for PD with NPS.Methods and analysisFrom their inception until 1 December 2023, we will search eight databases, including PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure, China Science Periodical Database, Chinese Citation Database and China Biology Medicine disc for randomised controlled trials examining the effectiveness of acupuncture for PD with NPS. Literature screening and data extraction will be carried out independently by the authors. RevMan V.5.3 software will be used for meta-analysis, while the Cochrane risk-of-bias tool will assess the potential for bias.Ethics and disseminationThis systematic review protocol does not require ethical approval because it does not include private information or data of participants. This article will be published in a peer-reviewed journal.PROSPERO registration numberCRD42022324494