Efficacy of lenvatinib in a patient with anaplastic thyroid cancer

• Published in: Endocrinology, diabetes & metabolism case reports Vol. 2017; no. 1; pp. 1 - 5
• Main Authors: Oishi, Kazuyuki, Takabatake, Daisuke, Shibuya, Yuichi
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 02.06.2017; Bioscientifica
• Subjects: Adult; Anaplastic thyroid cancer; Angiotensin receptor antagonists; Asian - Japanese; Blood pressure; CT scan; Dysphagia; Dyspnoea; Endoscopy; Female; Fine needle aspiration biopsy; FT3; FT4; Gastrostomy; Histopathology; Hypertension; Hypothyroidism; Japan; Levatinib; Levothyroxine; Neck mass; Novel Treatment; Oncology; PET scan; Stridor; Thyroglobulin; Thyroid; Thyroid antibodies; Thyroxine (T4); Tracheostomy; Triiodothyronine (T3); TSH; Tyrosine-kinase inhibitors; Vocal cord paresis; White blood cell count; Stridor; Gastrostomy; June; Thyroxine (T4); PET scan; Thyroid antibodies; Oncology; Tyrosine-kinase inhibitors; Levatinib; Dyspnoea; Histopathology; Asian - Japanese; Novel treatment; Adult; Female; Dysphagia; Blood pressure; Endoscopy; CT scan; Thyroid; Hypertension; FT3; Japan; FT4; TSH; Triiodothyronine (T3); Hypothyroidism; Vocal cord paresis; Fine needle aspiration biopsy; Neck mass; Levothyroxine; Anaplastic thyroid cancer; Angiotensin receptor antagonists; 2017; Thyroglobulin; White blood cell count; Tracheostomy
• ISSN: 2052-0573; 2052-0573
• DOI: 10.1530/EDM-16-0136

Summary We experienced a case of an 82-year-old woman who presented to our hospital with a 1-month history of dysphagia and dyspnea. Cervical contrast-enhanced computed tomography revealed diffuse thyroid neoplasms causing significant tracheal stenosis with tumors, particularly of the superior mediastinum, which were associated with an embolism of the brachiocephalic vein and suspected invasion to the bilateral common carotid arteries. Anaplastic thyroid cancer (ATC) was diagnosed by fine-needle aspiration; thus, emergency tracheostomy and gastrostomy were performed. We made a definitive diagnosis of ATC (T4bN0M0 Stage IVB) and initiated continuous lenvatinib administration at 24 mg/day. Although several adverse events occurred, the tumor size reduced remarkably over a short period. However, the patient died from rupture of the common carotid artery 30 days after treatment initiation. Here, we report our experience with lenvatinib therapy for ATC and include a literature review. Learning points: Lenvatinib is extremely effective for ATC. Lenvatinib has a much greater cytoreductive effect than traditional therapies, but it needs dose reduction or withdrawal because of treatment-related side effects. Lenvatinib may cause treatment-related carotid blowout syndrome, resulting in death for patients with invasion to the carotid artery.