Traceless liquid phase synthesis of piperazinediones

Liquid phase combinatorial synthesis (LPCS) of piperazinediones by the use of soluble polymer support is explored to generate libraries. Proline anchored polyethylene glycol monomethyl ether (PEG) underwent dipeptide formation with different Fmoc-amino acids in the presence of dicyclohexyl carbodiim...

Full description

Saved in:
Bibliographic Details
Published inCombinatorial chemistry & high throughput screening Vol. 6; no. 2; p. 133
Main Authors Sun, Chung-Ming, Swamy, K M K, Lin, Mei-Jung, Yeh, Wen-Ben, Chen, Fred Y, Tseng, Wei-Hong
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.03.2003
Subjects
Amino Acids - chemistry
Combinatorial Chemistry Techniques
Cyclization
Dicyclohexylcarbodiimide
Dipeptides - chemical synthesis
Fluorenes - chemistry
Hydrogen-Ion Concentration
Indicators and Reagents
Piperazines - chemical synthesis
Polyethylene Glycols
Online AccessGet more information

Cover

More Information
Summary:Liquid phase combinatorial synthesis (LPCS) of piperazinediones by the use of soluble polymer support is explored to generate libraries. Proline anchored polyethylene glycol monomethyl ether (PEG) underwent dipeptide formation with different Fmoc-amino acids in the presence of dicyclohexyl carbodiimide (DCC). Deprotection of Fmoc accompanied with the cleavage from polymer support with cyclization of dipeptide to piperazinediones offers a facile and effective way to prepare diverse combinatorial libraries. Excellent yields and purities were achieved by simple wash and precipitation method.
ISSN:1386-2073
DOI:10.2174/1386207033329733