Caerulein induced pancreatitis
[...]catecholamines exert anti-inflammatory effects on the cytokine network by inhibiting the production of proinflammatory cytokines such as tumour necrosis factor (TNF), interleukin (IL)-1β, IL-12, and interferon [GAMMA] (IFN-[GAMMA]), of which TNF and IL-1β have been implicated as mediators tha...
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Published in | Gut Vol. 52; no. 3; pp. 452 - 453 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
BMJ Publishing Group Ltd and British Society of Gastroenterology
01.03.2003
BMJ Publishing Group LTD BMJ Group |
Subjects | |
Online Access | Get full text |
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Summary: | [...]catecholamines exert anti-inflammatory effects on the cytokine network by inhibiting the production of proinflammatory cytokines such as tumour necrosis factor (TNF), interleukin (IL)-1β, IL-12, and interferon [GAMMA] (IFN-[GAMMA]), of which TNF and IL-1β have been implicated as mediators that play a proinflammatory role in acute pancreatitis. 3, 4 Secondly, in animal models of endotoxaemia, pretreatment with isoproterenol enhances the production of the anti-inflammatory cytokine IL-10 which has been shown to be protective in acute pancreatitis. 5, 6 Thirdly, in endotoxaemia models, β adrenergic stimulation results in reduction of levels of CC chemokines. 7 Fourthly, neutrophil migration to the pancreas, one of the hallmarks of acute pancreatitis, towards chemotactic stimuli such as C5a and lipopolysaccharide (LPS) is reduced by administration of β agonists but also affects LPS induced neutrophil degranulation in vivo. |
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Bibliography: | local:0520452a istex:CB175DC4876A0328F31256E73613984AF940D055 Correspondence to: Dr D J van Westerloo, Department of Gastroenterology, C2-321, Academic Medical Center, Meibergdreef 9, 1015 AZ, Amsterdam, the Netherlands; d.j.vanwesterloo@amc.uva.nl ark:/67375/NVC-FHZSCF1J-Q PMID:12584233 href:gutjnl-52-452-2.pdf |
ISSN: | 0017-5749 1468-3288 |
DOI: | 10.1136/gut.52.3.452-a |