Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop

• Published in: Radiation research Vol. 173; no. 2; p. 245
• Main Authors: Prasanna, Pataje G S, Blakely, William F, Bertho, Jean-Marc, Chute, John P, Cohen, Eric P, Goans, Ronald E, Grace, Marcy B, Lillis-Hearne, Patricia K, Lloyd, David C, Lutgens, Ludy C H W, Meineke, Viktor, Ossetrova, Natalia I, Romanyukha, Alexander, Saba, Julie D, Weisdorf, Daniel J, Wojcik, Andrzej, Yukihara, Eduardo G, Pellmar, Terry C
• Format: Journal Article
• Language: English
• Published: United States 01.02.2010
• Subjects: Biomarkers - analysis; Humans; Radiation Injuries - diagnosis; Radiation Injuries - genetics; Radiation Injuries - therapy
• ISSN: 1938-5404
• DOI: 10.1667/RR1993.1

Radiation exposures from accidents, nuclear detonations or terrorist incidents are unlikely to be homogeneous; however, current biodosimetric approaches are developed and validated primarily in whole-body irradiation models. A workshop was held at the Armed Forces Radiobiology Research Institute in May 2008 to draw attention to the need for partial-body biodosimetry, to discuss current knowledge, and to identify the gaps to be filled. A panel of international experts and the workshop attendees discussed the requirements and concepts for a path forward. This report addresses eight key areas identified by the Workshop Program Committee for future focus: (1) improved cytogenetics, (2) clinical signs and symptoms, (3) cutaneous bioindicators, (4) organ-specific biomarkers, (5) biophysical markers of dose, (6) integrated diagnostic approaches, (7) confounding factors, and (8) requirements for post-event medical follow-up. For each area, the status, advantages and limitations of existing approaches and suggestions for new directions are presented.