Insights into the Structural Complexities of SARS-CoV-2 for Therapeutic and Vaccine Development

SARS-CoV-2 is a disease that endangers both human life and the economy. There was an 11- month period of relative evolutionary standstill following the appearance of SARS-CoV-2 in late 2019. However, the emergence of clusters of mutations known as' variants of concern 'with variable viral...

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Published inCombinatorial chemistry & high throughput screening Vol. 26; no. 11; p. 1945
Main Authors Al Matar, Manaf, Mazila Ramli, Aizi Nor, Albarri, Osman, Yi, Choong Xin
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2023
Subjects
COVID-19
mutation
vaccine
SARS-COV-2
structural component
drug
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Summary:SARS-CoV-2 is a disease that endangers both human life and the economy. There was an 11- month period of relative evolutionary standstill following the appearance of SARS-CoV-2 in late 2019. However, the emergence of clusters of mutations known as' variants of concern 'with variable viral properties such as transmissibility and antigenicity defined the evolution of SARS-CoV-2. Several efforts have been made in recent months to understand the atomic level properties of SARS-CoV-2. A review of the literature on SARS-CoV-2 mutations is offered in this paper. The critical activities performed by different domains of the SARS-CoV-2 genome throughout the virus's entry into the host and overall viral life cycle are discussed in detail. These structural traits may potentially pave the way for the development of a vaccine and medication to combat the SARS-CoV-2 sickness.
ISSN:1875-5402
DOI:10.2174/1386207326666221108095705