Liver involvement in subjects with rheumatic disease

The liver is often overlooked as a target organ, with pathology either secondary to an underlying disease or due to the toxicity of therapies and the medical complications of extrahepatic diseases. It is thus important for the clinical rheumatologist to be aware of the diagnostic procedure to monito...

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Published inArthritis research & therapy Vol. 13; no. 3; p. 226
Main Authors Selmi, Carlo, De Santis, Maria, Gershwin, M Eric
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 01.01.2011
BioMed Central
Subjects
Autoimmunity - immunology
Comorbidity
Humans
Liver - immunology
Liver Diseases - diagnosis
Liver Diseases - epidemiology
Liver Diseases - immunology
Review
Rheumatic Diseases - epidemiology
Rheumatic Diseases - immunology
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Summary:The liver is often overlooked as a target organ, with pathology either secondary to an underlying disease or due to the toxicity of therapies and the medical complications of extrahepatic diseases. It is thus important for the clinical rheumatologist to be aware of the diagnostic procedure to monitor liver injury. Indeed, systemic rheumatologic diseases may be associated with liver abnormalities secondary to the presence of a coexisting autoimmune liver disease (particularly primary biliary cirrhosis or autoimmune hepatitis), the direct involvement of the liver parenchyma, or the impact of medical treatments (particularly methotrexate) on the liver. In addition, the rheumatologist should be aware of the impact of immunosuppressive agents on underlying viral infections, particularly viral hepatitis. We review herein the data on the role of the liver in the clinical management of systemic rheumatic diseases.
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ISSN:1478-6354
1478-6362
1478-6362
DOI:10.1186/ar3319