Observation and Analysis of Clinical Efficacy of Zhuang Medicine Lotus Acupuncture Cupping Stasis Therapy on Patients with Postherpetic Neuralgia

• Published in: Combinatorial chemistry & high throughput screening Vol. 26; no. 6; p. 1157
• Main Authors: Lai, Jingjing, Li, Meikang, Li, Jie, Han, Haitao, Huang, Jinming, Qin, Hongling, Li, Xiujuan, Tan, Lei, Xu, Jing, Peng, Jinxiu
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2023
• Subjects: Acupuncture Therapy; beta Catenin; Gabapentin; Humans; Interleukin-18; Lotus; Neuralgia, Postherpetic - therapy; Treatment Outcome; Tumor Necrosis Factor-alpha; lotus acupuncture cupping stasis therapy; Zhuang medicine; postherpetic neuralgia (PHN); clinical efficacy; action mechanism; PHN
• ISSN: 1875-5402
• DOI: 10.2174/1386207325666220819190418

To explore the clinical efficacy of Zhuang Medicine Lotus Acupuncture Cupping Stasis Therapy on patients with postherpetic neuralgia (PHN) and its action mechanism. 36 patients are randomly divided into Lotus Acupuncture Cupping Stasis Therapy group, pure cupping group and gabapentin group, with a total of five observation points for the first, fifth, tenth, fifteenth, and twentieth sessions of therapy (one session every three days). At each observation point, the venous blood of the patients is taken, and the contents of and changes in WNT3a, Frizzled8, β-catenin, IL-18, TNF-α, NR2B, NK-1 and SP are tested by ELISA, RT-PCR and WesternBlot, respectively. The VAS scores and safety of the patients in the three groups are compared. With increased time spent in therapy, the VAS scores of patients in each group decreased gradually and there was a significant reduction in pain in patients in the Lotus Acupuncture Cupping Stasis Therapy group compared to the gabapentin and pure cupping groups (P<0.05). The levels of IL-18, TNF-α, NK-1, SP, WNT3a, Frizzled 8 and β-catenin in the serum of all patients experienced a constant decline over time (P<0.05); the levels of the aforesaid factors in the serum of patients in the Lotus Acupuncture Cupping Stasis Therapy group dropped remarkably after the tenth session of therapy compared to those in gabapentin and pure cupping groups (P<0.05). Zhuang Medicine Lotus Acupuncture Cupping Stasis Therapy can significantly reduce the pain of PHN patients, with a good therapeutic effect, and it is worthy of clinical use.