Bispidine as a Privileged Scaffold

• Published in: Current topics in medicinal chemistry Vol. 16; no. 11; p. 1314
• Main Authors: Tomassoli, Isabelle, Gündisch, Daniela
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.05.2016
• Subjects: Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antidotes - chemistry; Antidotes - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Bridged Bicyclo Compounds, Heterocyclic - chemistry; Bridged Bicyclo Compounds, Heterocyclic - pharmacology; Humans; Ion Channels - chemistry; Ion Channels - metabolism; Neoplasms - diagnosis; Neoplasms - drug therapy; Platelet Aggregation Inhibitors - chemistry; Platelet Aggregation Inhibitors - pharmacology; Radioligand Assay; Receptors, Cell Surface - chemistry; Receptors, Cell Surface - metabolism
• ISSN: 1873-4294
• DOI: 10.2174/1568026615666150915111434

Thediazabicyclic molecule bispidine named by the chemist Carl Mannich in 1930, is a naturally occurring scaffold with interesting features. Bispidine can form different conformers, has high basicity, can attack dichloromethane, has metal ion coordination properties and interacts with nicotinic acetylcholine receptors. In this review we will discuss important properties, synthetic pathways and biological activities of bispidine and some derivatives. Bispidine can function as a scaffold for compounds with very diverse biological activities, e.g. interacting with ion channels, G-protein coupled receptors, and enzymes, and is even used for the development of new in vivo radiotracers.