Selective estrogen receptor modulators as brain therapeutic agents

AbstractSelective estrogen receptor modulators (SERMs), used for the treatment of breast cancer, osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger neuroprotective mechanisms and reduce neural damage in different experimental models of neural trauma, brain inflammat...

Full description

Saved in:
Bibliographic Details
Published inJournal of molecular endocrinology Vol. 46; no. 1; pp. R1 - R9
Main Authors Arevalo, María Angeles, Santos-Galindo, María, Lagunas, Natalia, Azcoitia, Iñigo, Garcia-Segura, Luis M
Format Journal Article
LanguageEnglish
Published England Society for Endocrinology 01.02.2011
BioScientifica
Subjects
Animals
Apoptosis - drug effects
Brain - drug effects
Brain - metabolism
Brain Diseases - drug therapy
Brain Diseases - metabolism
Brain Injuries - drug therapy
Encephalitis - drug therapy
Humans
Mood Disorders - drug therapy
Neurodegenerative Diseases - drug therapy
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Oxidative Stress - drug effects
Raloxifene Hydrochloride - therapeutic use
Receptors, Estrogen - metabolism
Review
Selective Estrogen Receptor Modulators - therapeutic use
Tamoxifen - therapeutic use
Online AccessGet full text

Cover

More Information
Summary:AbstractSelective estrogen receptor modulators (SERMs), used for the treatment of breast cancer, osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger neuroprotective mechanisms and reduce neural damage in different experimental models of neural trauma, brain inflammation, neurodegenerative diseases, cognitive impairment, and affective disorders. New SERMs with specific actions on neurons and glial cells may represent promising therapeutic tools for the brain.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0952-5041
1479-6813
DOI:10.1677/JME-10-0122