Pan-genomics: Insight into the Functional Genome, Applications, Advancements, and Challenges

• Published in: Current genomics Vol. 26; no. 1; pp. 2 - 14
• Main Authors: Sarawad, Akansha, Hosagoudar, Spoorti, Parvatikar, Prachi
• Format: Journal Article
• Language: English
• Published: United Arab Emirates Bentham Science Publishers 01.01.2025; Benham Science Publishers
• Subjects: Adaptability; Genetic analysis; Genetic diversity; Genomes; Genomic analysis; Genomics; Life Sciences, Genetics & Genomics, Genetics & Heredity; Phenotypes; Species diversity; conventional genomic; human genomics; evolution; telomer genome; OMIM; Pan-genomics
• ISSN: 1389-2029; 1875-5488
• DOI: 10.2174/0113892029311541240627111506

A pan-genome is a compilation of the common and unique genomes found in a given species. It incorporates the genetic information from all of the genomes sampled, producing a big and diverse set of genetic material. Pan-genomic analysis has various advantages over typical genomics research. It creates a vast and varied spectrum of genetic material by combining the genetic data from all the sampled genomes. Comparing pan-genomics analysis to conventional genomic research, there are a number of benefits. Although the most recent era of pan-genomic studies has used cutting-edge sequencing technology to shed fresh light on biological variety and improvement, the potential uses of pan-genomics in improvement have not yet been fully realized. Pangenome research in various organisms has demonstrated that missing genetic components and the detection of significant Structural Variants (SVs) can be investigated using pan-genomic methods. Many individual-specific sequences have been linked to biological adaptability, phenotypic, and key economic attributes. This study aims to focus on how pangenome analysis uncovers genetic differences in various organisms, including human, and their effects on phenotypes, as well as how this might help us comprehend the diversity of species. The review also concentrated on potential problems and the prospects for future pangenome research.