Assembled core-shell nanostructures of gold nanoparticles with biocompatible polymers toward biology

The present review focuses on core-shell nanostructures of spherical gold nanoparticles (Au NPs) and biocompatible polymers mainly from the view points of preparation approaches, nanocomposite properties and potential applications for biology. The preparation approaches are assorted into direct-redu...

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Published inCurrent topics in medicinal chemistry Vol. 14; no. 5; p. 595
Main Authors Li, Dongxiang, Li, Qianru, Hao, Xiongwen, Zhang, Yaojun, Zhang, Zhupeng, Li, Chunfang
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.03.2014
Subjects
Biocompatible Materials - chemistry
Biology
Gold - chemistry
Metal Nanoparticles - chemistry
Polymers - chemistry
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Summary:The present review focuses on core-shell nanostructures of spherical gold nanoparticles (Au NPs) and biocompatible polymers mainly from the view points of preparation approaches, nanocomposite properties and potential applications for biology. The preparation approaches are assorted into direct-reduction, covalent "graft-to", "graft-from" approach, surface bonding and physical adsorption. Various biocompatible polymers are involved such as the thermosensitive polymers, pH-responsive polymers, antibiofouling polymers, conductive polymers and several natural polymers. The encapsulating and loading properties, cellular uptake and drug release control, as well as biorecognition, targeting and sensing potential are discussed in connection with biological systems. These polymeric gold nanocomposites will have a great potential in biotechnology and life science but also face enormous challenge in future applications.
ISSN:1873-4294
DOI:10.2174/1568026614666140118204000