Targeting endothelial progenitor cells in cancer as a novel biomarker and anti-angiogenic therapy

• Published in: Current stem cell research & therapy Vol. 10; no. 2; p. 181
• Main Authors: Ammendola, Michele, Leporini, Christian, Luposella, Maria, Sacco, Rosario, Sammarco, Giuseppe, Russo, Emilio, Patruno, Rosa, De Sarro, Giovambattista, Ranieri, Girolamo
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2015
• Subjects: Angiogenesis Inhibitors - pharmacology; Angiogenesis Inhibitors - therapeutic use; Animals; Biomarkers, Tumor - physiology; Endothelial Progenitor Cells - drug effects; Endothelial Progenitor Cells - physiology; Humans; Molecular Targeted Therapy; Neoplasms - blood supply; Neoplasms - drug therapy; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - prevention & control
• ISSN: 2212-3946
• DOI: 10.2174/1574888X10666141126113622

Tumoral angiogenesis is mainly an endothelial cell-mediated process, which has been largely demonstrated to take on a crucial role in tumor growth, invasion, and metastasis. Thus, tumor-associated neovasculature represents a pivotal target in cancer therapy. Several mechanisms take part in the genesis of this pathological vasculature, most notably neoangiogenesis and postnatal vasculogenesis. These processes may also play a critical role in the resistance to antiangiogenic agents, leading to tumor progression. In particular, vasculogenesis is mediated by endothelial progenitor cells (EPCs), which include cellular subpopulations with different functional capacities. EPCs are able to proliferate, migrate, and differentiate into mature endothelial cells (ECs) in response to tumor growth, promoting the "angiogenic switch" and, consequently, inducing the invasion and metastases of cancer cells. Therefore, vasculogenesis mediated by EPCs represents an intriguing therapeutic target, both in early and late stages of cancer progression, thereby working as potential landmark for synthesizing novel and more effective anti-angiogenic drugs. Here, we aim to focus and to summarize several biological features of EPCs and EPC-based therapeutic approach with potential translation in human clinical trials.