Pathophysiology of erectile dysfunction

Erectile dysfunction (ED) is a major health problem as the population ages. Basic science research for the last two decades has expanded the knowledge on ED and identified several key molecular changes associated with the pathogenesis of ED, including nitric oxide (NO) / cyclic guanosine monophospha...

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Bibliographic Details
Published inCurrent drug targets Vol. 16; no. 5; p. 411
Main Authors Matsui, Hotaka, Sopko, Nikolai A, Hannan, Johanna L, Bivalacqua, Trinity J
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.05.2015
Subjects
Animals
Cardiovascular Diseases - complications
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 2 - complications
Erectile Dysfunction - epidemiology
Erectile Dysfunction - etiology
Erectile Dysfunction - metabolism
Erectile Dysfunction - pathology
Humans
Male
Risk Factors
Signal Transduction
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Summary:Erectile dysfunction (ED) is a major health problem as the population ages. Basic science research for the last two decades has expanded the knowledge on ED and identified several key molecular changes associated with the pathogenesis of ED, including nitric oxide (NO) / cyclic guanosine monophosphate (cGMP) / protein kinase G (PKG) pathway, RhoA/Rho-associated protein kinase (ROCK) signaling pathway, reactive oxygen species (ROS), renin-angiotensin system (RAS) and tumor necrosis factor-alpha (TNF-α). The causes of ED are classified into aging, vasculogenic, neurogenic, endocrinological, drug-induced and psychogenic. ED is often associated with systemic diseases, such as diabetes and cardiovascular diseases. In this review, we will review the molecular mechanisms of ED and known mechanisms behind ED associated with systemic diseases.
ISSN:1873-5592
DOI:10.2174/138945011605150504114041