Anorectal and inguinal lymphogranuloma venereum among men who have sex with men in Amsterdam, the Netherlands: trends over time, symptomatology and concurrent infections

• Published in: Sexually transmitted infections Vol. 89; no. 7; pp. 548 - 552
• Main Authors: de Vrieze, Nynke Hesselina Neeltje, van Rooijen, Martijn, Schim van der Loeff, Maarten Franciscus, de Vries, Henry John C
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group 01.11.2013; BMJ Publishing Group LTD
• Subjects: Adult; Anal Canal - pathology; Asymptomatic; Bacterial diseases; Bacterial diseases of the genital system; Biological and medical sciences; Chlamydia; Chlamydia trachomatis - isolation & purification; Coinfection - epidemiology; Coinfection - pathology; Constipation; Epidemiology. Vaccinations; General aspects; Gonorrhea; Hepatitis; Homosexuality, Male; Human bacterial diseases; Human infectious diseases. Experimental studies and models; Humans; Incidence; Infections; Infectious diseases; Inguinal Canal - pathology; Laboratories; Lymphogranuloma Venereum - epidemiology; Lymphogranuloma Venereum - pathology; Male; Medical sciences; Middle Aged; Netherlands - epidemiology; Outpatient care facilities; Sexually transmitted diseases; STD; Syphilis; Trends; Ulcers; Netherlands; Europe; United States > US; Infection; Human; Symptomatology; Homosexuality; Sexually transmitted disease; Bacteriosis; Lymphogranuloma venereum; Male; Chlamydiosis; Anorectal; Inguinal; LYMPHOGRANULOMA VENEREUM; HOMOSEXUALITY; HIV; CHLAMYDIA TRACHOMATIS; EPIDEMIOLOGY (CLINICAL)
• ISSN: 1368-4973; 1472-3263
• DOI: 10.1136/sextrans-2012-050915

Objectives To examine lymphogranuloma venereum (LGV) trends over time among men who have sex with men (MSM) visiting the Amsterdam sexually transmitted infection (STI) clinic; to investigate anal LGV symptomatology; and to examine the positivity and characteristics of anorectal and inguinal LGV. Methods We included MSM consultations from whom a swab (from anorectum, bubo or an genital ulcer) was taken for Chlamydia trachomatis (Ct) screening. Anorectal swabs were taken from all MSM who reported receptive anorectal intercourse in the preceding 6 months. Ct positive samples were further tested with a pmpH PCR to identify L-genovars. Patient symptoms, clinical and anoscopic inflammatory signs, and STI co-infections were noted; Gram-stained anorectal mucosal smears were examined. Results Between January 2005 and June 2012, 48 570 consultations among MSM were conducted. In 3628/35 650 visits, anorectal Ct infections were diagnosed, including 411 anal LGV (1.2%). Moreover, 65/1649 genital ulcer swabs were Ct positive; 10 were inguinal LGV (0.6%) Since January 2011 a significant increase in the positivity of LGV occurred (p<0.0001). 89 (27.2%) anorectal LGV cases were asymptomatic. HIV prevalence among anorectal LGV cases was significantly higher (p=0.008) than among inguinal LGV cases. STI co-morbidity in anorectal LGV cases remained invariably high during the study period. Conclusions Since January 2011, LGV positivity in MSM consultations in Amsterdam has risen significantly. The great majority comprise anal LGV; inguinal LGV is rare. Anal LGV is asymptomatic in a quarter of cases. In all MSM with anal Ct infections LGV should be excluded, irrespective of symptoms or inflammatory signs.