Should creatine kinase be checked in all boys presenting with speech delay?

• Published in: Archives of disease in childhood Vol. 92; no. 7; pp. 647 - 649
• Main Authors: Lundy, Claire T, Doherty, Gary M, Hicks, Elaine M
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01.07.2007; BMJ Publishing Group Ltd; BMJ Publishing Group LTD
• Subjects: Analysis; Biomarkers - blood; Child, Preschool; Childhood speech disorders; Children & youth; Creatine kinase; Creatine Kinase - blood; Delayed Speech; Diagnosis; Duchenne muscular dystrophy; Dystrophy; Early Diagnosis; Evidence-Based Medicine; Humans; Language; Language Acquisition; Language Development Disorders - etiology; Male; Medical screening; Meta Analysis; Muscular dystrophy; Muscular Dystrophy, Duchenne - complications; Muscular Dystrophy, Duchenne - diagnosis; Ordination; Population; Speech disorders; Speech Disorders - etiology; Speech disorders in children; Walking
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/adc.2007.117028

Suggests clinical criteria et al case note regional paediatric Previous analysis in 1995 3.2 years that should justify a (2000) 2 review neuromuscular from the same clinic showed When neonatal diagnosis CK measurement 4 clinic mean age of diagnosis of 4.5 excluded, mean age rose to 1995-1998 years in a total of 51 boys 4.5 years 72% had been seen by another hospital or community doctor prior to the diagnosis being considered Cotton Meta analysis 1224 children Looked specifically at verbal Impairments reported in Highlighted the influence et al 2a with muscular and performance IQ language scores that motor co-ordination (1998) 3 dystrophy Results suggested no significant Population mean IQ in may have on IQ tests difference overall but considered DMD 1 SD lower than the possibility of subgroups in normal population within the muscular dystrophy population with lower than expected language scores Smith Cohort study 19 930 Picked up 2 affected boys 1.7% not walking at 18 Concluded that population et al 1b participants months.