Drug Repurposing Strategies for Non-Cancer to Cancer Therapeutics

Global efforts invested for the prevention and treatment of cancer need to be repositioned to develop safe, effective, and economic anticancer therapeutics by adopting rational approaches of drug discovery. Drug repurposing is one of the established approaches to reposition old, clinically approved...

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Published inAnti-cancer agents in medicinal chemistry
Main Authors Singhal, Shipra, Maheshwari, Priyal, Krishnamurthy, Praveen Thaggikuppe, Patil, Vaishali M
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.2022
Subjects
Anticancer drugs
Drug repurposing
Drug discovery
Non-cancer drugs
Cancer therapeutics
Multitargeting
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Summary:Global efforts invested for the prevention and treatment of cancer need to be repositioned to develop safe, effective, and economic anticancer therapeutics by adopting rational approaches of drug discovery. Drug repurposing is one of the established approaches to reposition old, clinically approved off patent noncancer drugs with known targets into newer indications. The literature review suggests key role of drug repurposing in the development of drugs intended for cancer as well as noncancer therapeutics. A wide category of noncancer drugs namely, drugs acting on CNS, anthelmintics, cardiovascular drugs, antimalarial drugs, anti-inflammatory drugs have come out with interesting outcomes during preclinical and clinical phases. In the present article a comprehensive overview of the current scenario of drug repurposing for the treatment of cancer has been focused. The details of some successful studies along with examples have been included followed by associated challenges.
ISSN:1875-5992
DOI:10.2174/1871520622666220317140557