Retarded development of XO conceptuses during early pregnancy in the mouse

The growth and development of XO and XX mice were compared from 7 1/4 to 18 1/2 days of gestation. The 7 1/4-day XO egg cylinders were retarded in development (and consequently small) when compared with XX egg cylinders, and this lag in development remained until 10 1/2 days. By 12 1/4 days there wa...

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Bibliographic Details
Published inJournal of reproduction & fertility Vol. 68; no. 2; pp. 387 - 393
Main Authors Burgoyne, P S, Tam, P P, Evans, E P
Format Journal Article
LanguageEnglish
Published England 01.07.1983
Subjects
Aneuploidy
Animals
Birth Weight
Female
Fetal Growth Retardation - genetics
Mice
Mice, Inbred Strains - genetics
Mice, Inbred Strains - physiology
Pregnancy
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Summary:The growth and development of XO and XX mice were compared from 7 1/4 to 18 1/2 days of gestation. The 7 1/4-day XO egg cylinders were retarded in development (and consequently small) when compared with XX egg cylinders, and this lag in development remained until 10 1/2 days. By 12 1/4 days there was a considerable degree of 'catch-up', but this was not fully maintained. A subgroup of very severely retarded XO fetuses were preferentially located near the cervix. The placentas of XO fetuses were of normal size until 18 1/2 days when they were significantly larger than those of XX controls.
ISSN:0022-4251
1470-1626
1741-7899
DOI:10.1530/jrf.0.0680387