Recent Advances in the Development of Pyrazolopyridines as Anticancer Agents
Cancer, especially malignant tumor, is a serious threat to people's life and health. It is recognized as an enormous challenge in the 21st century. Continuous efforts are needed to overcome this problem. Pyrazolopyridine nucleus, similar in structure to purine, shows a variety of biological act...
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Published in | Anti-cancer agents in medicinal chemistry Vol. 22; no. 9; p. 1643 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Netherlands
01.01.2022
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Subjects | |
Online Access | Get more information |
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Summary: | Cancer, especially malignant tumor, is a serious threat to people's life and health. It is recognized as an enormous challenge in the 21st century. Continuous efforts are needed to overcome this problem. Pyrazolopyridine nucleus, similar in structure to purine, shows a variety of biological activities, which is mainly attributed to the antagonistic nature towards the natural purines in many biological processes. This has aroused enormous attention for many researchers. At present, a large number of new chemical entities containing pyrazolopyridine nucleus have been found as anticancer agents. In this review we summarize novel pyrazolopyridine-containing derivatives with biological activities. Furthermore, we outline the relationships between the structures of variously modified pyrazolopyridines and their anticancer activity. |
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ISSN: | 1875-5992 |
DOI: | 10.2174/1871520621666210901102832 |