Recent Advances in the Development of Pyrazolopyridines as Anticancer Agents

Cancer, especially malignant tumor, is a serious threat to people's life and health. It is recognized as an enormous challenge in the 21st century. Continuous efforts are needed to overcome this problem. Pyrazolopyridine nucleus, similar in structure to purine, shows a variety of biological act...

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Bibliographic Details
Published inAnti-cancer agents in medicinal chemistry Vol. 22; no. 9; p. 1643
Main Authors Gu, Xiaotong, Ma, Shutao
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2022
Subjects
Antineoplastic Agents - chemistry
Humans
Neoplasms - drug therapy
Pyrazoles - chemistry
Pyrazoles - pharmacology
Pyridines - chemistry
Structure-Activity Relationship
biological activity
structures-activity relationship
heterocyclic compounds
pyrazolopyridines
Cancer
anticancer agents
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Summary:Cancer, especially malignant tumor, is a serious threat to people's life and health. It is recognized as an enormous challenge in the 21st century. Continuous efforts are needed to overcome this problem. Pyrazolopyridine nucleus, similar in structure to purine, shows a variety of biological activities, which is mainly attributed to the antagonistic nature towards the natural purines in many biological processes. This has aroused enormous attention for many researchers. At present, a large number of new chemical entities containing pyrazolopyridine nucleus have been found as anticancer agents. In this review we summarize novel pyrazolopyridine-containing derivatives with biological activities. Furthermore, we outline the relationships between the structures of variously modified pyrazolopyridines and their anticancer activity.
ISSN:1875-5992
DOI:10.2174/1871520621666210901102832