The Natural Product Oridonin as an Anticancer Agent: Current Achievements and Problems

• Published in: Current pharmaceutical biotechnology Vol. 25; no. 6; p. 655
• Main Authors: Hu, Xiangyan, Huang, Sisi, Ye, Shiying, Jiang, Jinhuan
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2024
• Subjects: Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Apoptosis - drug effects; Biological Products - pharmacology; Biological Products - therapeutic use; Diterpenes, Kaurane - pharmacology; Diterpenes, Kaurane - therapeutic use; Humans; Neoplasms - drug therapy; Neoplasms - metabolism; Signal Transduction - drug effects; signaling pathway; apoptosis; molecular mechanism; herbal medicine; anticancer; Oridonin
• ISSN: 1873-4316
• DOI: 10.2174/1389201024666230821110116

Oridonin, an active diterpenoid isolated from traditional Chinese herbal medicine, has received a rising attention for its remarkable roles in cancer therapy. In recent years, increasing evidences have revealed that oridonin inhibits the occurrence and development of tumor cells through multiple mechanisms, including induction of apoptosis and autophagy, cell cycle arrest, and inhibition of angiogenesis as well as migration and invasion. In addition, several molecular signal targets have been identified, including ROS, EGFR, NF-κB, PI3K/Akt, and MAPK. In this paper, we review considerable knowledge about the molecular mechanisms and signal targets of oridonin, which has been studied in recent years. It is expected that oridonin may be developed as a novel anti-tumor herbal medicine in human cancer treatment.