The effects of prostaglandin and mating on release of LH in the female rabbit

The release of LH in response to prostaglandin (PG) treatment of female rabbits in various reproductive states was compared with the surge following mating. Intracarotid infusion of PGE-2 or PGF-2alpha (0-3--900 microgram/h) into non-receptive and pseudopregnant does resulted in small, 2--4-fold ele...

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Bibliographic Details
Published inJournal of reproduction & fertility Vol. 51; no. 1; pp. 87 - 92
Main Authors Carlson, J C, Wong, A P, Perrin, D G
Format Journal Article
LanguageEnglish
Published England 01.09.1977
Subjects
Animals
Copulation
Estrus
Female
Luteinizing Hormone - blood
Luteinizing Hormone - metabolism
Male
Pregnancy
Prostaglandins E - pharmacology
Prostaglandins F - pharmacology
Rabbits
Stimulation, Chemical
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Summary:The release of LH in response to prostaglandin (PG) treatment of female rabbits in various reproductive states was compared with the surge following mating. Intracarotid infusion of PGE-2 or PGF-2alpha (0-3--900 microgram/h) into non-receptive and pseudopregnant does resulted in small, 2--4-fold elevations in jugular vein LH concentration. Similar doses of PGF-2alpha in oestrogen-pretreated, oestrous does stimulated a 13-fold increase in plasma LH levels. Mating resulted in a much larger release of LH, as plasma levels increased approximately 60-fold from 1-1 +/- 0-2 (S.E.M.) ng/ml to 67-8 +/- 10-5 ng/ml. These results indicate that PG can stimulate the hypothalamic-hypophysial axis to release LH in non-receptive, pseudopregnant and oestrogen-pretreated, oestrous rabbits.
ISSN:0022-4251
1470-1626
1741-7899
DOI:10.1530/jrf.0.0510087