Protective or Inhibitory Effect of Pharmacological Therapy on Cardiac Ischemic Preconditioning: A Literature Review

Ischemic preconditioning (IP) is an innate phenomenon, triggered by brief, non-lethal cycles of ischemia/reperfusion applied to a tissue or organ that confers tolerance to a subsequent more prolonged ischemic event. Once started, it can reduce the severity of myocardial ischemia associated with some...

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Published inCurrent vascular pharmacology Vol. 20; no. 5; p. 409
Main Authors de Paula, Leonardo Jorge Cordeiro, Uchida, Augusto Hiroshi, Rezende, Paulo Cury, Soares, Paulo, Scudeler, Thiago Luis
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2022
Subjects
Heart
Humans
Ischemia
Ischemic Preconditioning, Myocardial
Myocardial Ischemia
Percutaneous Coronary Intervention - adverse effects
ischemia-reperfusion injury
cardioprotection
Ischemic preconditioning
signaling pathways
heart disease
cardiac pharmacology
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Summary:Ischemic preconditioning (IP) is an innate phenomenon, triggered by brief, non-lethal cycles of ischemia/reperfusion applied to a tissue or organ that confers tolerance to a subsequent more prolonged ischemic event. Once started, it can reduce the severity of myocardial ischemia associated with some clinical situations, such as percutaneous coronary intervention (PCI) and intermittent aortic clamping during coronary artery bypass graft surgery (CABG). Although the mechanisms underlying IP have not been completely elucidated, several studies have shown that this phenomenon involves the participation of cell triggers, intracellular signaling pathways, and end-effectors. Understanding this mechanism enables the development of preconditioning mimetic agents. It is known that a range of medications that activate the signaling cascades at different cellular levels can interfere with both the stimulation and the blockade of IP. Investigations of signaling pathways underlying ischemic conditioning have identified a number of therapeutic targets for pharmacological manipulation. This review aims to present and discuss the effects of several medications on myocardial IP.
ISSN:1875-6212
DOI:10.2174/1570161120666220819163025