Neurological outcome following isolated 10–12 mm fetal ventriculomegaly
The normal width of the atrium of the lateral ventricle is less than or equal to 9 mm. 1 Severe ventriculomegaly (or hydrocephalus) is defined as widths greater than 15 mm. Mild values of 10-15 mm confer an increased risk for aneuploidy, malformations and impaired postnatal neurological outcome, alt...
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Published in | Archives of disease in childhood. Fetal and neonatal edition Vol. 94; no. 4; pp. F311 - F312 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
01.07.2009
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | The normal width of the atrium of the lateral ventricle is less than or equal to 9 mm. 1 Severe ventriculomegaly (or hydrocephalus) is defined as widths greater than 15 mm. Mild values of 10-15 mm confer an increased risk for aneuploidy, malformations and impaired postnatal neurological outcome, although the frequency of the association is variable. 2 - 4 However, the outcome of fetal non-progressive isolated forms of lateral ventriculomegaly with atrial widths between 10 and 12 mm has been little studied. All subjects, n = 20 Subjects with impaired neurological outcome, n = 4 Subjects with impaired neurological outcome who later recovered, n = 2 Subjects with impaired neurological outcome,n = 2 Fetus 1 Fetus 2 Fetus 3 Fetus 4 Sex, male/female 14/6 1/3 F F M F Gestational age at diagnosis, weeks 24.5 (SD 3.8), 18-32 25.5 (SD 4.2), 21-30 23 28 21 30 Type of lateral ventriculomegaly, ML/BL 11/9 2/2 ML BL BL ML Lateral ventriculomegaly at birth 8, resolved (6 ML, 2 BL) 2, resolved (1 ML, 1 BL) Persistent Persistent Resolved Resolved 12, persistent (6 ML, 2 BL) 2, persistent (1 ML, 1 BL) Right lateral atrium width, mm 10.0 (SD 1.2), 6.6-12.0 10.4 (SD 0.5), 10.0-11.0 11.0 10.8 10.0 10.0 Left lateral atrium width, mm 9.5 (SD 1.6), 7.0-12.0 8.8 (SD 2.1), 7.0-11.2 7.0 11.2 10.0 7.0 Difference between lateral atrial widths, mm 1.63 (SD 1.56), 0-3.7 1.85 (SD 1.95), 0-4.0 4.0 0.4 0 3.0 Gestational age at birth, weeks 37.5 (SD 2.3), 34-42 37.5 (SD 0.6), 37-38 38 38 37 37 Weight at birth, kg 3.1 (SD 0.65), 2.0-4.65 3.0 (SD 0.5), 2.2-3.4 3.0 2.2 3.4 3.3 Apgar score at 1 min 7.9 (SD 1.02), 7-9 8.2 (SD 0.95), 7-9 8 7 9 9 Apgar score at 5 min 8.9 (SD 0.82), 7-10 9 (SD 0.81), 8-10 9 8 10 9 Age at first Griffith test, months 26.15 (SD 24.25), 3-75 7 (SD 4.9), 3-13 13 9 3 3 Age at last Griffith test, months 42.7 (SD 25.82), 13-95 22.5 (SD 8.8), 15-32 32 28 15 15 Values are mean (SD), range. |
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Bibliography: | ark:/67375/NVC-L0NQ8BJV-8 PMID:19542317 href:fetalneonatal-94-F311.pdf local:fetalneonatal;94/4/F311 istex:9A49D1A97D0EBE2971DFC5A9226CDC1BB2EA5489 ArticleID:fn134312 SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 |
ISSN: | 1359-2998 1468-2052 |
DOI: | 10.1136/adc.2007.134312 |