Pluripotency-regulating networks provide basis for reprogramming

The reprogramming of somatic cells into induced pluripotent stem cells or iPS cells can be achieved by the ectopic expression of defined factors. Patient-specific iPS cell lines can be derived and used for disease modeling, drug and toxicology screening, cellular replacement therapies and basic rese...

Full description

Saved in:
Bibliographic Details
Published inCurrent molecular medicine Vol. 13; no. 5; p. 695
Main Authors Aksoy, I, Stanton, L W
Format Journal Article
LanguageEnglish
Published Netherlands 01.06.2013
Subjects
Animals
Cell Cycle
Cell Differentiation
Cells, Cultured
Cellular Reprogramming
Embryonic Stem Cells - physiology
Epigenesis, Genetic
Genetic Engineering
Humans
Induced Pluripotent Stem Cells - physiology
RNA, Untranslated - genetics
Signal Transduction
Transcription Factors - genetics
Transcription Factors - metabolism
Online AccessGet more information

Cover

More Information
Summary:The reprogramming of somatic cells into induced pluripotent stem cells or iPS cells can be achieved by the ectopic expression of defined factors. Patient-specific iPS cell lines can be derived and used for disease modeling, drug and toxicology screening, cellular replacement therapies and basic research. However, reprogramming is slow and inefficient and numerous methods have been described aiming to improve this process. These methods include screening for new genetic factors and chemical compounds, and the engineering of new synthetic factors. Here, we review recent progress made in this field and show how a better understanding of the ES (embryonic stem) cell transcriptional network is important for efficient reprogramming.
ISSN:1875-5666
DOI:10.2174/1566524011313050002