Penetrance of phaeochromocytoma in RET G533C carriers differs between South America and Europe

In a recent issue of Endocrine-Related Cancer, Castinetti et al. reported a different natural history of phaeochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) patients between Europe and South America (Castinetti et al. 2017). The authors retrospectively collected data about the phaeochro...

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Published inEndocrine-related cancer Vol. 25; no. 9; pp. L49 - L51
Main Authors Maciel, Rui M B, Bim, Larissa V, Camacho, Cleber P, Cerutti, Janete M
Format Journal Article
LanguageEnglish
Published England Bioscientifica Ltd 01.09.2018
Society for Endocrinology & BioScientifica Ltd
Subjects
Cancer
Exons
Multiple endocrine neoplasia
Pheochromocytoma
to the Editor
South America
Central Europe
Europe
Western Europe
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Summary:In a recent issue of Endocrine-Related Cancer, Castinetti et al. reported a different natural history of phaeochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) patients between Europe and South America (Castinetti et al. 2017). The authors retrospectively collected data about the phaeochromocytoma in MEN 2 patients carrying RET mutations on exons 10 and 11 in 14 countries from South America, Southern Europe, Western Europe and Central Europe. They showed that phaeochromocytoma penetrance is lower (53%) in South America compared to South Europe, Western Europe and Central Europe.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
ISSN:1351-0088
1479-6821
DOI:10.1530/ERC-17-0349