Balb/Cj Male Mice Do Not Feminize after Infection with Larval Taenia crassiceps

• Published in: The Journal of parasitology Vol. 93; no. 1; pp. 190 - 191
• Main Authors: Aldridge, Jerry R, Jennette, Mary A, Kuhn, R. E
• Format: Journal Article
• Language: English
• Published: Lawrence, KS American Society of Parasitologists 01.02.2007; Allen Press Inc
• Subjects: 17β-Estradiol; Age; Analysis of Variance; Animals; Biological and medical sciences; Cysticercosis - immunology; Cysticercosis - physiopathology; Cysticercosis - veterinary; Enzyme-Linked Immunosorbent Assay; Estradiol - blood; Experiments; Female; Female animals; Females; Fundamental and applied biological sciences. Psychology; General aspects; General aspects and techniques. Study of several systematic groups. Models; Haplotypes; Host-Parasite Interactions; Immune response; Immune system; Infections; Invertebrates; Larvae; Larval development; Lymphoma; Male; Male animals; Males; Memory interference; Mice; Mice, Inbred BALB C - classification; Mice, Inbred BALB C - genetics; Mice, Inbred BALB C - physiology; Parasite hosts; Parasites; Parasitology; RESEARCH NOTES; Rodent Diseases - immunology; Rodent Diseases - parasitology; Rodent Diseases - physiopathology; Rodents; Serum levels; Sex Factors; Sex hormones; Sexual Behavior, Animal; Steroids; Taenia - immunology; Taenia - physiology; Taenia crassiceps; Testosterone; Testosterone - blood; Variance analysis; Rodentia; Plathelmintha; Parasite; Male; Cestoda; Infection; Vertebrata; Mammalia; Larva; Mouse; Helmintha; Taenia crassiceps; Invertebrata
• ISSN: 0022-3395; 1937-2345
• DOI: 10.1645/GE-947R.1

Balb/cJ mice fail to mount an immune response capable of clearing infection with larval Taenia crassiceps. Additionally, male Balb/cJ mice display a lag in larval growth of approximately 3 wk as compared to growth in female mice. It has been reported that male Balb/ cAnN mice generate a protective immune response early in infection, and become permissive to larval growth after they feminize (200-fold increase in serum estradiol and 90% decrease in serum testosterone). To determine if a different strain of Balb/c mice (Balb/cJ) also feminize, serum was collected from infected male mice for 16 wk and levels of 17-β-estradiol and testosterone were measured via ELISA. In addition, the mounting responses of 12- and 16-wk infected male mice, as well as uninfected control mice, were determined after isolation with a female mouse. The results of these experiments show that male Balb/cJ mice do not feminize during infection with larval T. crassiceps. There was no significant change in serum levels of either 17-β-estradiol or testosterone during the course of infection (>16 wk). Moreover, there was no significant decrease in the number of times infected male mice mounted the female mouse as compared to uninfected controls. These results suggest that there may be variances between the substrains of Balb/c mice that lead to the phenotypic differences reported for male Balb/cJ and Balb/cAnN mice.