A 38 year old woman with hypotensive shock at the onset of menstruation: case outcome

A bone marrow biopsy sample showed normocellularity and multifocal aggregates of abnormal spindle shaped mast cells (figs 1 , 2 , and 3 ). Indolent systemic mastocytosis is distinguished from illnesses with similar clinical manifestations principally by the presence of raised serum tryptase concentr...

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Bibliographic Details
Published inBMJ Vol. 338; no. mar09 1; p. b247
Main Authors Serrano Villar, Sergio, Perez-Somarriba, Juncal, Sainz Costa, Talia, Winstanley, Sarah, Santillana Lopez, Tomas, Escribano Mora, Luis, Orejas Gonzalez, Baltasar
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 09.03.2009
Subjects
Adult
Allergies
Biomarkers - blood
Biopsy
Bone Marrow Cells - pathology
Bones
Female
Histamine
Humans
Hypotension - etiology
Mastocytosis, Systemic - complications
Mastocytosis, Systemic - pathology
Menstruation Disturbances - complications
Mutation
Shock - etiology
Tryptases - blood
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Summary:A bone marrow biopsy sample showed normocellularity and multifocal aggregates of abnormal spindle shaped mast cells (figs 1 , 2 , and 3 ). Indolent systemic mastocytosis is distinguished from illnesses with similar clinical manifestations principally by the presence of raised serum tryptase concentrations and histological features, although these criteria are not always present in monoclonal mast cell activation syndrome.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0959-8138
1468-5833
1756-1833
DOI:10.1136/bmj.b247