The potential for targeting oncogenic WNT/beta-catenin signaling in therapy

There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches a...

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Bibliographic Details
Published inCurrent drug targets Vol. 9; no. 7; p. 532
Main Authors Ewan, Kenneth B R, Dale, Trevor C
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.07.2008
Subjects
Animals
Apoptosis - drug effects
beta Catenin - metabolism
Cell Differentiation - drug effects
Drug Delivery Systems
Humans
Neoplasms - drug therapy
Neoplasms - physiopathology
Signal Transduction - drug effects
Wnt Proteins - metabolism
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Summary:There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.
ISSN:1873-5592
DOI:10.2174/138945008784911787