Vitamin D and cardiovascular disease: a novel agent for reducing cardiovascular risk?

Vitamin D deficiency is a well-established risk factor for bone disease. Emerging data suggest a pleiotropic role of this agent in a variety of functions in humans. Epidemiological studies indicate an inverse association between vitamin D deficiency and the prevalence of cardiovascular disease (CVD)...

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Published inCurrent vascular pharmacology Vol. 8; no. 5; p. 720
Main Authors Anagnostis, Panagiotis, Athyros, Vasilios G, Adamidou, Fotini, Florentin, Matilda, Karagiannis, Asterios
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.09.2010
Subjects
Adult
Atherosclerosis - blood
Atherosclerosis - epidemiology
Atherosclerosis - prevention & control
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Cardiovascular Diseases - prevention & control
Child
Dietary Supplements
Humans
Prevalence
Risk Factors
Treatment Outcome
Vitamin D - blood
Vitamin D - physiology
Vitamin D - therapeutic use
Vitamin D Deficiency - drug therapy
Vitamin D Deficiency - physiopathology
Vitamin D Deficiency - prevention & control
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Summary:Vitamin D deficiency is a well-established risk factor for bone disease. Emerging data suggest a pleiotropic role of this agent in a variety of functions in humans. Epidemiological studies indicate an inverse association between vitamin D deficiency and the prevalence of cardiovascular disease (CVD), as well as individual cardiometabolic risk factors, such as hypertension, diabetes, dyslipidemia and the metabolic syndrome. Moreover, vitamin D deficiency has been implicated in the atherosclerotic process. This review considers current data regarding the role of vitamin D deficiency in the development of CVD and addresses the effect of supplementation on cardiovascular outcomes.
ISSN:1875-6212
DOI:10.2174/157016110792006978