Infiltration of neutrophil polymorphonuclear leucocytes into the endometrial stroma at the time of implantation of ova and the initiation of the oil decidual cell reaction in mice
Polymorphonuclear leucocytes (polymorphs) were found in the endometrial stroma adjacent to implanting blastocysts approximately 100 h after mating. Areas of uterus not containing a blastocyst had very few polymorphs. Ovariectomized mice were treated with hormones to render them sensitive to a decidu...
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Published in | Journal of reproduction & fertility Vol. 91; no. 1; pp. 365 - 369 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Society for Reproduction and Fertility
01.01.1991
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Subjects | |
Online Access | Get full text |
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Summary: | Polymorphonuclear leucocytes (polymorphs) were found in the endometrial stroma adjacent to implanting blastocysts approximately
100 h after mating. Areas of uterus not containing a blastocyst had very few polymorphs. Ovariectomized mice were treated
with hormones to render them sensitive to a decidual stimulus, the intraluminal injection of arachis oil. Areas of uterus
responding to the oil (as indicated by the Pontamine Sky Blue reaction) showed an influx of leucocytes into the endometrial
stroma between 16 and 36 h after the application of the decidual stimulus. The polymorphs were largely neutrophils. The injection
of oil into non-sensitized uteri did not result in polymorph infiltration nor did the injection of physiological saline (which
is not deciduogenic) into sensitized uteri. It is concluded that during the early stages of decidualization there is attraction
of polymorphs from the blood into the stroma.
Keywords: leucocytes; polymorphs; endometrium; decidualization; implantation |
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ISSN: | 1470-1626 0022-4251 1741-7899 |
DOI: | 10.1530/jrf.0.0910365 |