Prenatal diagnosis of beta-thalassaemia by fetal red cell concentration with anti-AB serum
Prenatal diagnosis by globin chain synthesis analysis on fetal blood samples obtained by placental aspiration was performed in two pregnancies at risk for beta-thalassaemia. Since both fathers had blood group AB, and both mothers had group O, fetal red cell concentration from maternal-fetal mixtures...
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Published in | Journal of medical genetics Vol. 16; no. 5; pp. 366 - 368 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
BMJ Publishing Group Ltd
01.10.1979
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | Prenatal diagnosis by globin chain synthesis analysis on fetal blood samples obtained by placental aspiration was performed in two pregnancies at risk for beta-thalassaemia. Since both fathers had blood group AB, and both mothers had group O, fetal red cell concentration from maternal-fetal mixtures was obtained with the aid of anti-AB serum. With this approach it was possible to carry out globin chain synthesis analysis with very small amounts of fetal blood. Heterozygous and normal genotypes were ascertained and confirmed after birth. |
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Bibliography: | local:jmedgenet;16/5/366 istex:684DDB8D2EABA17986629F14986D774450EE597E PMID:513082 ark:/67375/NVC-4VZ97BZW-F href:jmedgenet-16-366.pdf ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-2593 1468-6244 1468-6244 |
DOI: | 10.1136/jmg.16.5.366 |