Prenatal diagnosis of beta-thalassaemia by fetal red cell concentration with anti-AB serum

Prenatal diagnosis by globin chain synthesis analysis on fetal blood samples obtained by placental aspiration was performed in two pregnancies at risk for beta-thalassaemia. Since both fathers had blood group AB, and both mothers had group O, fetal red cell concentration from maternal-fetal mixtures...

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Bibliographic Details
Published inJournal of medical genetics Vol. 16; no. 5; pp. 366 - 368
Main Authors Furbetta, M, Valenti, C, Ximenes, A, Angius, A, Tuveri, T, Fioretti, P, Cao, A
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd 01.10.1979
BMJ Publishing Group LTD
Subjects
ABO Blood-Group System
Agglutination Tests
Female
Fetal Blood - analysis
Globins - analysis
Humans
Immune Sera
Pregnancy
Prenatal Diagnosis
Thalassemia - diagnosis
Thalassemia - genetics
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Summary:Prenatal diagnosis by globin chain synthesis analysis on fetal blood samples obtained by placental aspiration was performed in two pregnancies at risk for beta-thalassaemia. Since both fathers had blood group AB, and both mothers had group O, fetal red cell concentration from maternal-fetal mixtures was obtained with the aid of anti-AB serum. With this approach it was possible to carry out globin chain synthesis analysis with very small amounts of fetal blood. Heterozygous and normal genotypes were ascertained and confirmed after birth.
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PMID:513082
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href:jmedgenet-16-366.pdf
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ISSN:0022-2593
1468-6244
1468-6244
DOI:10.1136/jmg.16.5.366